About TriMix-gel® (prostaglandin, papaverine, phentolamine)

What is TriMix-gel®?(prostaglandin, papaverine, phentolamine)

Each dose contains trimix in powder form which is energized into a gel at time of use. Trimix ingredients have been tested and widely prescribed for many years for improvement of sexual health.

What storage conditions are needed for TriMix-gel®?(prostaglandin, papaverine, phentolamine)

Keep TriMix-gel in the container it came in, tightly closed, and out of reach of children. Store it at room temperature under 77 degrees Fahrenheit and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. TriMix-gel should be discarded after 6 months.


  • Tell your doctor and pharmacist if you are allergic to alprostadil/prostaglandin or any other drugs.
  • Tell your doctor and pharmacist what prescription and nonprescription medications you are taking.
  • Tell your doctor if you have or have ever had anemia, bleeding disorders, sickle cell disease, leukemia, cancer, kidney or liver disease.

What other information should I know?

Keep all appointments with your physician.

Use precautions such as condoms to reduce the risk of spreading sexually transmitted diseases and human immunodeficiency virus (HIV) infection.

Use a condom to prevent transfer of this medication if your partner is pregnant or if your partner is sensitive to prostaglandin or TrMix-gel®.

Do not let anyone else use your medication.

Do not use if you are sensitive to prostaglandin/alprostadil.

Compounding Pharmacy

The pharmacy has always relied on the “triad” patient-physician-pharmacist relationship. Through this relationship, patient needs are determined by a physician, who chooses a treatment regimen that may include a compounded medication. Physicians often prescribe compounded medications for reasons that include (but are not limited to) the following situations:

  • When needed medications are discontinued by or generally unavailable from pharmaceutical companies, often because the medications are no longer profitable to manufacture;
  • When the patient is allergic to certain preservatives, dyes or binders in available off-the-shelf medications;
  • When treatment requires tailored dosage strengths for patients with unique needs (for example, an infant);
  • When a pharmacist can combine several medications the patient is taking to increase compliance;
  • When the patient cannot ingest the medication in its commercially available form and a pharmacist can prepare the medication in cream, liquid or other form the patient can easily take; and
  • When medications require flavor additives to make them more palatable for some patients, most often children.


Insurance policies greatly differ as to the extent of prescription coverage or whether certain medications will be covered at all.

On the back of your insurance card or prescription card you will find a telephone number for customer service. Call that number and ask for the address of where to send your receipt for prescription reimbursement.

The amount of your reimbursement will vary due to the conditions and terms of your individual policy. Your insurance company will tell you:

  • Whether they will cover medications
  • How much they will cover

Due to the variations in insurance companies coverage, a universal insurance claim form can be provided to you. Whether your insurance company covers this medicine or not, your TriMix-gel® will always be available for purchase after the pharmacy receives your physicians prescription.