About TriMix-gel® ED Alternative

TriMix-gel® is used as an alternative for patients who have failed on Viagra, Levitra or Cialis and who cannot bring themselves to self-inject with a needle into their own penis.

Erectile Dysfunction Treatment - Physicians Section

Physicians Section

For a patient who failed on PDE5 inhibitors and cannot use a needle to self-inject his penis, TriMix-gel® has been used as an alternative.

How to Apply TriMix-gel®

Caution: Video of Actual Patient Applying Medicine.

How to Order TriMix-gel®

The ingredients of TriMix-gel® include medicine listed in the US Pharmacopeia and therefore must be prescribed by a licensed physician.

TriMix-gel® ED Alternative

TriMix-gel® and other ED Alternatives

Q: How does TriMix-gel® compare to Viagra®, Levitra®, Cialis® and other ED alternatives?

A: TriMix-gel® is an easy to apply gel that during clinical trials achieved a 40% success rate among men who have failed with Viagra®, Levitra®, Cialis® and other medications for Erectile Dysfunction, (formerly known as impotence).

TriMix-gel® has been used as a new treatment for erectile dysfunction. Each dose contains trimix in powder form which is energized into a gel at time of use. Trimix ingredients have been tested and widely prescribed by doctors for many years to maintain sexual health.

  • TriMix-gel® has been used for patients who fail on PDE5 Inhibitor tablets (Viagra®, Levitra®, Cialis®) or cannot tolerate the side effects. Study
  • TriMix-gel® has been prescribed by doctors for erectile dysfunction patients, formerly known as impotence, who cannot or will not self-inject with a needle.
  • Real medicine, not an herbal remedy. The active ingredients in TriMix-gel® require a doctor’s prescription and are listed in the US Pharmacopoeia.
  • No need to visit a special Erectile Dysfunction Treatment Clinic. Your own Family Doctor or Urologist can prescribe TriMix-gel® for you.
  • Combining PDE5 inhibitor tablets (Viagra®, Levitra®, Cialis®) and TriMix-gel® may be effective in patients who have failed with each treatment individually.(Nehra A. Rev Urol. 2007 Summer;9(3):99-105)

Causes of Erectile Dysfunction

ED has two classifications.

Psychogenic: the origin of ED comes from influences in the mind or psychological.
Organic: there is a physical factor behind the condition.

The most common is organic. This usually results in a lack of adequate blood supply to the penis during the need for an erection or the penis’ inability to maintain an erection sufficient for penetration during sexual intercourse.

Erectile Dysfunction Treatment

Several options exist for ED treatment:

Pill Form

Viagra®, Cialis® & Levitra® are three approved tablets currently available for Erectile Dysfunction treatment. They need to be taken 20 minutes to 1 hour before sexual intercourse. The period of time of half life, during which they can potentially work can vary between 3 hours up to 17.5 hours.


Can be injected into the penis before sexual intercourse.

Vacuum Erection Device

Also known as “the pump”, it is a plastic cylindrical tube placed over the penis with a pump mechanism that removes the air from the tube. This creates a vacuum which works to draw blood into the penis helping it attain an erection. Then a constriction device is placed at the base of the penis to retain enough blood in the penis for sexual intercourse.

Hormone Replacement Therapy

Low testosterone has been treated with transdermal patches, topical ointments, or intramuscular injections.


The last resort, end of the line ED treatment is the implantation of rods into each of the penis’ two erection chambers called the corpora cavernosa.

Combination Therapy

Prostaglandin/PGE1, the principle active ingredient in trimix uses an energy pathway known as cyclic adenosine monophosphate (cAMP). PDE5 inhibitors such as Viagra®, Cialis® and Levitra® use the energy pathway known as cyclic guanosine monophosphate (cGMP). For patients who have failed either of these ED treatments individually, it has been observed the combination of using both at the same time may be a viable option.

Combination Therapy

Relaxation of the smooth muscles in the penis’ erection chambers, the corpora cavernosa, is a critical step in attaining an erection. This relaxation is in part regulated by cyclic adenosine monophosphate or cAMP and cyclic guanosine monophosphate or cGMP.

Prostaglandin E/alprostadil, a principle active ingredient in TriMix-gel®, uses the energy pathway known as cyclic adenosine monophosphate (cAMP). PDE5 inhibitors such as Viagra®, Cialis® and Levitra® use the energy pathway known as cyclic guanosine monophosphate (cGMP).

For patients who failed on Viagra®, Levitra® or Cialis® tablets and who have failed on prostaglandin/alprostadil based medications, combining these two may be more effective for patients where these treatments have failed on monotherapy. Since both cAMP and cGMP mediated vasodilation can lead to penile erection, combining therapies that incorporate both pathways may succeed when single therapies fail. (Nehra A et al International Journal of Impotence Research. 2002 Feb:14 Suppl 1;S38-42)

Viagra®, Levitra® or Cialis® used with TriMix-gel® in combination therapy may be a viable alternative when both modalities have failed in monotherapy.

Drug Studies

STUDIES WITH TRIMIX GEL IN MEN WHO FAILED PHOSPHODIESTERASE INHIBITORS – Published in Journal of Urology Supplement, J. Urol. 179 (4): 431, 2008

Erectile Dysfunction Treatment - Order Form

ED Treatment - Order Form

Trimix ED Treatment - Order Form