ED has two classifications.
Psychogenic: the origin of ED comes from influences in the mind or psychological.
Organic: there is a physical factor behind the condition.
The most common is organic. This usually results in a lack of adequate blood supply to the penis during the need for an erection or the penis’ inability to maintain an erection sufficient for penetration during sexual intercourse.
Viagra®, Cialis® & Levitra® are three approved tablets currently available for Erectile Dysfunction treatment. They need to be taken 20 minutes to 1 hour before sexual intercourse. The period of time of half life, during which they can potentially work can vary between 3 hours up to 17.5 hours.
Can be injected into the penis before sexual intercourse.
Vacuum Erection Device
Also known as “the pump”, it is a plastic cylindrical tube placed over the penis with a pump mechanism that removes the air from the tube. This creates a vacuum which works to draw blood into the penis helping it attain an erection. Then a constriction device is placed at the base of the penis to retain enough blood in the penis for sexual intercourse.
Hormone Replacement Therapy
Low testosterone has been treated with transdermal patches, topical ointments, or intramuscular injections.
The last resort, end of the line ED treatment is the implantation of rods into each of the penis’ two erection chambers called the corpora cavernosa.
Prostaglandin/PGE1, the principle active ingredient in trimix uses an energy pathway known as cyclic adenosine monophosphate (cAMP). PDE5 inhibitors such as Viagra®, Cialis® and Levitra® use the energy pathway known as cyclic guanosine monophosphate (cGMP). For patients who have failed either of these ED treatments individually, it has been observed the combination of using both at the same time may be a viable option.
Relaxation of the smooth muscles in the penis’ erection chambers, the corpora cavernosa, is a critical step in attaining an erection. This relaxation is in part regulated by cyclic adenosine monophosphate or cAMP and cyclic guanosine monophosphate or cGMP.
Prostaglandin E/alprostadil, a principle active ingredient in TriMix-gel®, uses the energy pathway known as cyclic adenosine monophosphate (cAMP). PDE5 inhibitors such as Viagra®, Cialis® and Levitra® use the energy pathway known as cyclic guanosine monophosphate (cGMP).
For patients who failed on Viagra®, Levitra® or Cialis® tablets and who have failed on prostaglandin/alprostadil based medications, combining these two may be more effective for patients where these treatments have failed on monotherapy. Since both cAMP and cGMP mediated vasodilation can lead to penile erection, combining therapies that incorporate both pathways may succeed when single therapies fail. (Nehra A et al International Journal of Impotence Research. 2002 Feb:14 Suppl 1;S38-42)
Viagra®, Levitra® or Cialis® used with TriMix-gel® in combination therapy may be a viable alternative when both modalities have failed in monotherapy.